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1

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

Hatfield, Stephen M, Sitkovsky, Michail

Journal:

Current Opinion in Pharmacology

Year:

2016

Language:

english

File:

PDF, 549 KB

english, 2016

2

Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo

Gregorio Gomez, Michail V Sitkovsky

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2003

Language:

english

File:

PDF, 45 KB

english, 2003

3

Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

Cronstein, Bruce N., Sitkovsky, Michail

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2016

Language:

english

File:

PDF, 426 KB

english, 2016

4

Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods || Protocol for Assaying CTL Activity Against Toxoplasma gondii

Sitkovsky, Michail V., Henkart, Pierre A.

Year:

1993

Language:

english

File:

PDF, 161 KB

english, 1993

5

An efficient route to xanthine based A2A adenosine receptor antagonists and functional derivatives

LaBeaume, Paul, Dong, Ma, Sitkovsky, Michail, Jones, Elizabeth V., Thomas, Rhiannon, Sadler, Sara, Kallmerten, Amy E., Jones, Graham B.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 248 KB

english, 2010

6

Model organisms: Animal Models of sepsis: setting the stage

Buras, Jon A., Holzmann, Bernhard, Sitkovsky, Michail

Journal:

Nature Reviews Drug Discovery

Year:

2005

Language:

english

File:

PDF, 399 KB

english, 2005

7

Physiological regulation of acute inflammation by A2A adenosine receptor

Dmitriy E. Lukashev, Akio Ohta, Michail V. Sitkovsky

Journal:

Drug Development Research

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

8

The A2aR adenosine receptor controls cytokine production in iNKT cells

Michael Nowak, Lydia Lynch, Simon Yue, Akio Ohta, Michail Sitkovsky, Steven P. Balk, Mark. A. Exley

Journal:

European Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

9

Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1α in activated human T lymphocytes

Dmitriy Lukashev, Michail Sitkovsky

Journal:

Human Immunology

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

10

Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation?

Frank A. Redegeld, Charles C. Caldwell, Michail V. Sitkovsky

Journal:

Trends in Pharmacological Sciences

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

11

Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

Hatfield, Stephen M., Sitkovsky, Michail

Journal:

Year:

2015

Language:

english

File:

PDF, 2.60 MB

english, 2015

12

Study of A2A adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A2A receptor-unrelated lymphotoxicity

Sergey G Apasov, Jiang-Fan Chen, Patrick T Smith, Michael A Schwarzschild, J Stephen Fink, Michail V Sitkovsky

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 230 KB

english, 2000

13

Cyclic AMP-Dependent Protein Kinase as a Part of the Possible Down-regulating Pathway in the Antigen Receptor-Regulated Cytotoxic T Lymphocyte Conjugate Formation and Granule Exocytosis

MICHAIL V. SITKOVSKY, GUIDO TRENN, HAJIME TAKAYAMA

Journal:

Annals of the New York Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 522 KB

english, 1988

14

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Silva, Murillo, Nguyen, Thao H., Philbrook, Phaethon, Chu, Matthew, Sears, Olivia, Hatfield, Stephen, Abbott, Robert K., Kelsoe, Garnett, Sitkovsky, Michail V.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.85 MB

english, 2017

15

Purification and recognition of recombinant mouse P2X1 receptors expressed in a baculovirus system

Liping Chen, James P. Hardwick, Peter McPhie, Michail V. Sitkovsky, Kenneth A. Jacobson

Journal:

Drug Development Research

Year:

2000

Language:

english

File:

PDF, 292 KB

english, 2000

16

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?

Michail V. Sitkovsky, Akio Ohta

Journal:

Trends in Immunology

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

17

Sufficient numbers of anti-tumor T cells is a condition of maximal efficacy of anti-hypoxia-A2-adenosinergic drugs during cancer immunotherapy

Sitkovsky, Michail V

Journal:

Current Opinion in Pharmacology

Year:

2020

File:

PDF, 224 KB

2020

18

Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors

Sitkovsky, Michail, Lukashev, Dmitriy

Journal:

Nature Reviews Immunology

Year:

2005

Language:

english

File:

PDF, 452 KB

english, 2005

19

TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1α

Sonja Hägele, Babak Behnam, Emanuela Borter, Jonathan Wolfe, Uwe Paasch, Dmitriy Lukashev, Michail Sitkovsky, Roland H. Wenger, Dörthe M. Katschinski

Journal:

Year:

2006

Language:

english

File:

PDF, 803 KB

english, 2006

20

Aspects of the general biology of adenosine A2A signaling

Bertil B. Fredholm, Yijuang Chern, Rafael Franco, Michail Sitkovsky

Journal:

Progress in Neurobiology

Year:

2007

Language:

english

File:

PDF, 876 KB

english, 2007

21

HIF-1α Deficiency Perturbs T and B Cell Functions

Kojima, Hidefumi, Sitkovsky, Michail, Cascalho, Marilia

Journal:

Current Pharmaceutical Design

Year:

2003

Language:

english

File:

PDF, 110 KB

english, 2003

22

Potential use of an antagonist of cAMP-dependent protein kinase to block inhibition and modulate T-cell receptor-triggered activation of cytotoxic T-lymphocytes

Hajime Takayama, Michail V. Sitkovsky

Journal:

Journal of Pharmaceutical Sciences

Year:

1989

Language:

english

File:

PDF, 399 KB

english, 1989

23

Immunomodulatory and neuroprotective effects of inosine

György Haskó, Michail V. Sitkovsky, Csaba Szabó

Journal:

Trends in Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 290 KB

english, 2004

24

Adenosine Negative Feedback on A2A Adenosine Receptors Mediates Hyporesponsiveness in Chronically Septic Mice

Belikoff, Bryan, Hatfield, Stephen, Sitkovsky, Michail, Remick, Daniel G.

Journal:

Year:

2011

Language:

english

File:

PDF, 187 KB

english, 2011

25

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

Huang, Steve, Apasov, Sergey, Koshiba, Masahiro, Sitkovsky, Michail

Journal:

Year:

1997

Language:

english

File:

PDF, 1.28 MB

english, 1997

26

The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases

Manfred Thiel, Charles C Caldwell, Michail V Sitkovsky

Journal:

Microbes and Infection

Year:

2003

Language:

english

File:

PDF, 185 KB

english, 2003

27

Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods || T-Cell-Mediated Cytotoxicity: A Historical Note

Sitkovsky, Michail V., Henkart, Pierre A.

Year:

1993

Language:

english

File:

PDF, 589 KB

english, 1993

28

Immunosuppressive effects of extracellular adenosine on immune cells: Implications for the pathogenesis of ADA SCID and immunomodulation

Gregorio Gomez, Sergey Apasov, Michail V. Sitkovsky

Journal:

Drug Development Research

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

29

The G S Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center

Abbott, Robert K., Silva, Murillo, Labuda, Jasmine, Thayer, Molly, Cain, Derek W., Philbrook, Phaethon, Sethumadhavan, Shalini, Hatfield, Stephen, Ohta, Akio, Sitkovsky, Michail

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 1.77 MB

english, 2017

30

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

Ohta, Akio, Sitkovsky, Michail

Journal:

Year:

2001

Language:

english

File:

PDF, 232 KB

english, 2001

31

Role of Extracellular ATP and P1 and P2 Classes of Purinergic Receptors in T-cell Development and Cytotoxic T Lymphocyte Effector Functions

SERGEY APASOV, MASAHIRO KOSHIBA, FRANK REDEGELD, MICHAIL V. SITKOVSKY

Journal:

Immunological Reviews

Year:

1995

Language:

english

File:

PDF, 3.85 MB

english, 1995

32

Use of the A2A adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

Michail V Sitkovsky

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

33

Targeting hypoxia–A2A adenosine receptor-mediated mechanisms of tissue protection

Dmitriy Lukashev, Akio Ohta, Michail Sitkovsky

Journal:

Drug Discovery Today

Year:

2004

Language:

english

File:

PDF, 75 KB

english, 2004

34

[Part 1: Biological Sciences] || Isolation and Partial Characterization of Concanavalin A Receptors on Cloned Cytotoxic T Lymphocytes

Michail V. Sitkovsky, Mark S. Pasternack, James P. Lugo, John R. Klein and Herman N. Eisen

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 1.32 MB

english, 1984

35

Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury

Nowak-Machen, Martina, Schmelzle, Moritz, Hanidziar, Dusan, Junger, Wolfgang, Exley, Mark, Otterbein, Leo, Wu, Yan, Csizmadia, Eva, Doherty, Glen, Sitkovsky, Michail, Robson, Simon C.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 2.53 MB

english, 2013

36

In vivo T Cell Activation in Lymphoid Tissues is Inhibited in the Oxygen-Poor Microenvironment

Ohta, Akio, Diwanji, Rohan, Kini, Radhika, Subramanian, Meenakshi, Ohta, Akiko, Sitkovsky, Michail

Journal:

Frontiers in Immunology

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

37

The adenosinergic immunomodulatory drugs

Akio Ohta, Michail Sitkovsky

Journal:

Current Opinion in Pharmacology

Year:

2009

Language:

english

File:

PDF, 216 KB

english, 2009

38

Extracellular ATP in T-Lymphocyte Activation: Possible Role in Effector Functions

Antonio Filippini, Rolf E. Taffs and Michail V. Sitkovsky

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.32 MB

english, 1990

39

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

Trenn, Guido, Takayama, Hajime, Sitkovsky, Michail V.

Journal:

Year:

1987

File:

PDF, 387 KB

1987

40

Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer

Sitkovsky, Michail, Ohta, Akio

Journal:

Journal of Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 314 KB

english, 2013

41

A Serine/Threonine Phosphorylation Site in the Ectodomain of a T Cell Receptor β Chain is Required for Activation by Superantigen

Lukashev, Dmitriy E., Caldwell, Charles C., Chen, Pearl, Apasov, Sergey G., Margulies, David H., Sitkovsky, Michail V.

Journal:

Journal of Receptor and Signal Transduction Research

Year:

2003

Language:

english

File:

PDF, 1.95 MB

english, 2003

42

Lessons from the A2A Adenosine Receptor AntagonistâEnabled Tumor Regression and Survival in Patients with Treatment-Refractory Renal Cell Cancer

Sitkovsky, Michail V.

Journal:

Cancer Discovery

Year:

2020

File:

PDF, 2.71 MB

2020

43

Global or directed exocytosis?

Sitkovsky, Michail V., Paul, William E.

Journal:

Year:

1988

File:

PDF, 265 KB

1988

44

From ‘Hellstrom Paradox–to anti-adenosinergic cancer immunotherapy

Dmitriy Lukashev, Michail Sitkovsky, Akio Ohta

Journal:

Purinergic Signalling

Year:

2007

Language:

english

File:

PDF, 161 KB

english, 2007

45

Design and evaluation of xanthine based adenosine receptor antagonists: Potential hypoxia targeted immunotherapies

Thomas, Rhiannon, Lee, Joslynn, Chevalier, Vincent, Sadler, Sara, Selesniemi, Kaisa, Hatfield, Stephen, Sitkovsky, Michail, Ondrechen, Mary Jo, Jones, Graham B.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

46

P hysiological C ontrol of I mmune R esponse and I nflammatory T issue D amage by H ypoxia -I nducible F actors and A denosine A 2A R eceptors *

Sitkovsky, Michail V., Lukashev, Dmitriy, Apasov, Sergey, Kojima, Hidefumi, Koshiba, Masahiro, Caldwell, Charles, Ohta, Akio, Thiel, Manfred

Journal:

Annual Review of Immunology

Year:

2004

Language:

english

File:

PDF, 440 KB

english, 2004

47

Cell-mediated cytotoxicity: contact and secreted factors

Sergei Apasov, Frank Redegeld, Michail Sitkovsky

Journal:

Current Opinion in Immunology

Year:

1993

Language:

english

File:

PDF, 1016 KB

english, 1993

48

Caveats and cautions for the therapeutic targeting of the anti-inflammatory A2 adenosine receptors

Ohta, Akio, Sitkovsky, Michail

Journal:

Nature Reviews Drug Discovery

Year:

2006

Language:

english

File:

PDF, 30 KB

english, 2006

49

Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs

Dmitriy E Lukashev, Patrick T Smith, Charles C Caldwell, Akio Ohta, Sergey G Apasov, Michail V Sitkovsky

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 356 KB

english, 2003

50

Phosphorylation of T-lymphocyte plasma membrane-associated proteins by ectoprotein kinases: implications for a possible role for ectophosphorylation in T-cell effector functions

Frank A Redegeld, Pat Smith, Sergey Apasov, Michail V Sitkovsky

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1997

Language:

english

File:

PDF, 627 KB

english, 1997

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